Chlamydia antigens and corresponding dna fragments and uses...

Details Chlamydia antigens and corresponding dna fragments and uses... Chlamydia antigens and corresponding dna fragments and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 39/118 (2006.01) A61P 31/04 (2006.01) C07K 14/295 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2365196

The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 60kDa cysteine-rich membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 60kDa cysteine-rich membrane protein gene in the host. Modifications are possible within the scope of this invention.

La présente invention concerne une méthode d'immunisation d'un organisme hôte, tel qu'un humain, par un acide nucléique, notamment l'ADN, contre des maladies provoquées par une infection due à une souche Chlamydia, spécifiquement C. pneumoniae, en utilisant un vecteur contenant une séquence nucléotidique codant une protéine de 60 kDa riche en cystéine de souche Chlamydia pneumoniae, et un promoteur pour effectuer l'expression du gène de la protéine membranaire de 60 kD riche en cystéine chez l'organisme hôte. Des modifications sont possibles dans le champ de l'invention.

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