Chlamydia antigens and corresponding dna fragments and uses...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/118 (2006.01) A61K 31/7088 (2006.01) C07K 14/295 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2373021

The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding full-length, 5'-truncated or 3'- truncated 76kDa protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 76kDa protein gene in the host. Modifications are possible within the scope of this invention.

L'invention concerne un procédé d'immunisation par l'acide nucléique, y compris par l'ADN, d'un organisme hôte, y compris un organisme humain, contre une maladie due à une infection causée par une souche Chlamydia, en particulier, C. pneumoniae. A cet effet, on utilise un vecteur contenant une séquence nucléotide codant pour toute la longueur, une protéine 76kDa tronquée en 5' ou en 3' issue d'une souche Chlamydia pneumoniae et un promoteur de façon à activer l'expression de la protéine 76kDa du gène dans l'organisme hôte. Des modifications sont possibles dans le champ d'application de la présente invention.

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