Chlamydia trachomatis antigens for vaccine and diagnostic use

Details Chlamydia trachomatis antigens for vaccine and diagnostic use Chlamydia trachomatis antigens for vaccine and diagnostic use

A - Human Necessities

61

K

A61K 39/118 (2006.01) C07K 14/295 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2585011

The present invention is related to antigens from Chlamydia trachomatis which are recognized by specific antibodies from individuals infected with Chlamydia or which can induce T cells from the same individuals to secrete gamma- interferon. The T cell reactive antigens are present in a whole-cell lysate and have apparent molecular weights of 5-12, 16-20, 25-35 and 58-74 kDa as determined by SDS-PAGE. The antigens of the invention are useful in vaccines but also as diagnostic compositions.

La présente invention concerne des antigènes de Chlamydia trachomatis qui sont reconnus par des anticorps spécifiques issus d'individus infectés par des Chlamydia ou qui peuvent agir sur des lymphocytes T des mêmes individus pour qu'ils sécrètent l'interféron gamma. Les antigènes réactifs aux lymphocytes T, sont présents dans une lysat de cellule entière, et ont des poids moléculaires apparents de 5-12, 16-20, 25-35 et 58-74 kDa tels que déterminés par SDS-PAGE. Les antigènes de l'invention sont utiles dans des vaccins et en tant que compositions diagnostiques.

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