Chlorambucil derivatives

Details Chlorambucil derivatives Chlorambucil derivatives

C - Chemistry, Metallurgy

07

J

260/47

C07J 41/00 (2006.01) C07J 1/00 (2006.01)

Patent

CA 1123427

ABSTRACT OF THE DISCLOSURE The present invention provides Chlorambucil derivatives having the formula (I). Image (I) wherein R represents a hydrogen atom or an acyl group such as Image , Image , Image , Image and n is 1 or 2, which are antitumor agents having a selective effective against certain cancer cells. The Chlorambucil deri- vatives can be produced by binding Chlorambucil with the hydroxyl group at the 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formula X(CH2)nCOOH, X(CH2)nCOX, HOOC(CH2)n- COOH and XOC(CH2)nCOX wherein n is 1 or 2 and X represents a halo- gen atom.

333654

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