Chlorhexidine glucomate-containing, stabilized aqueous...

A - Human Necessities – 61 – K

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A61K 31/49 (2006.01) A61K 9/00 (2006.01) A61K 31/155 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2204067

An aqueous pharmaceutical preparation is provided containing chloride ion and stably containing chlorhexidine gluconate, characterized in that said preparation further contains at least one pharmaceutically acceptable polycarboxylic acid of the formula I: HOOC-(CR11-CR12)n -COOH (I) wherein n is an integer 1, 2 or 3; i is a positive integer not more than n; R11 and R12, when n=1, independently from each other, are H, -OH or -COOH; each of R11, R12, R21 and R 22, when n=2 , is H, -OH or -COOH, but not all of them are H simultaneously; and each of R11, R12, R21, R22, R31 and R32, when n=3, is H, -OH or -COOH, but two adjacent carbons in no case contain four hydrogen atoms in total; or a pharmaceutically acceptable salt thereof.

Préparation pharmaceutique aqueuse, renfermant l'ion chlorure et, de façon stable, du gluconate de chlorhexidine; elle se caractérise aussi par le fait qu'elle contient au moins un acide polycarboxylique acceptable en pharmacie, de formule I, soit HOOC-(CR11-CR12)n -COOH (I), dans laquelle n est l'entier 1, 2 ou 3; i est un entier positif inférieur ou égale à n; lorsque n=1, R11 et R12 sont, indépendamment l'un de l'autre, H, -OH ou -COOH; lorsque n=2, R11, R12, R21 et R22 sont chacun H, -OH ou -COOH, sans toutefois être tous H simultanément; lorsque n=3, R11, R12, R21, R22, R31 et R32 sont chacun H, -OH ou -COOH, mais deux carbones voisins ne peuvent jamais porter en tout quatre hydrogènes; sel dérivé de ce produit, acceptable en pharmacie.

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