Chloride linker for solid phase organic synthesis

Details Chloride linker for solid phase organic synthesis Chloride linker for solid phase organic synthesis

C - Chemistry, Metallurgy

08

F

C08F 8/18 (2006.01) C08F 12/08 (2006.01) C08F 112/08 (2006.01) C08F 212/08 (2006.01)

Patent

CA 2289719

This invention relates to a linker for use in solid phase synthesis, its preparation and methods of use. The linker consists essentially of an alkoxy substituted phenyl ring bearing an optionally substituted benzylic chloride. Synthetic components bearing a suitable nucleophile can displace the chlorine atom and form a covalent linkage to the support.

L'invention a trait à un lieur utile dans des synthèses en phase solide, à la préparation et à des procédés d'utilisation de celui-ci. Le lieur consiste essentiellement en un noyau phénylique substitué par un alcoxy portant un chlorure benzylique éventuellement substitué. Des constituants synthétiques portant un nucléophile approprié peuvent déplacer l'atome de chlore et former une liaison covalente par rapport au support.

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