Chlorination of sugars

C - Chemistry – Metallurgy – 07 – H

Patent

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260/233

C07H 5/02 (2006.01) C07H 13/02 (2006.01) C07H 13/04 (2006.01) C07H 13/08 (2006.01)

Patent

CA 1320722

ABSTRACT A process for the chlorination of sucrose or a derivative thereof, comprises reaction of the sucrose or derivative thereof with thionyl chloride and a nitrogen base at a ratio of about 1 molar equivalent (ME) of thionyl chloride and about 1 ME of base for every ME of free hydroxyl, in a non-reactive moderately polar solvent. The process is particularly suitable for the preparation of sucralose.

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