C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/238, 260/253
C07D 239/95 (2006.01) C07C 205/44 (2006.01) C07C 205/59 (2006.01) C07D 211/18 (2006.01) C07D 211/32 (2006.01) C07D 211/42 (2006.01) C07D 211/46 (2006.01) C07D 239/96 (2006.01) C07D 267/10 (2006.01) C07D 307/68 (2006.01) C07D 319/20 (2006.01) C07D 403/00 (2006.01) C07D 413/04 (2006.01)
Patent
CA 1146546
Abstract 2,4-Diaminoquinazolines of the formula Image ---(I) wherein Y1 is hydrogen or chloro Y2 is OR, Y3 is hydrogen or OR such that when Y1 is hydrogen Y3 is OR and when Y1 is chloro Y3 is hydrogen or OR, and the pharmaceutically acceptable salts thereof; R represents an alkyl group having from one to three carbon atoms; taken separately, R1 and R2 are each hydrogen, alkyl having from one to five carbon atoms, cyclo- alkyl having from three to eight carbon atoms, alkenyl or alkynyl each having from three to five carbon atoms or hydroxy substituted alkyl having from two to five carbon atoms, when taken together with the nitrogen atom to which they are attached R1 and R2 form a substituted or unsubstituted heterocyclic group optionally containing an atom of oxygen, sulfur or a second atom of nitrogen as a ring member; their use as antihypertensive agents, pharmaceutical com- positions containing them and intermediates for their production.
363579
Bindra Jasjit S.
Hess Hans-Jurgen E.
Shah Praful K.
Limited Pfizer
Smart & Biggar
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