Chlorobenzyl phenoxy alkoxylic compounds

Details Chlorobenzyl phenoxy alkoxylic compounds Chlorobenzyl phenoxy alkoxylic compounds

C - Chemistry, Metallurgy

07

C

260/295, 260/476

C07C 59/70 (2006.01) C07C 59/68 (2006.01) C07C 69/712 (2006.01) C07C 205/37 (2006.01) C07D 213/30 (2006.01)

Patent

CA 1136146

Abstract Compounds of formula (I) (I) Image wherein R1 and R2 are the same or different lower alkyls, R3 is hydrogen, a lower alkyl optionally substituted with pyridylmethyl or an ion of a pharmaceutically acceptable metal, and R4 is hydrogen or nitro; and the acid addition salts of said formula (I) compounds with pharmaceutically acceptable acids when R3 is pyridylmethyl. When R4 is nitro, R3 and/or R2 may also represent hydrogen. These compounds are useful in the treatment of hypercholesterolemia and hyperlipldemia because of their high effectiveness in reducing the level of cholesterol and lipids in the blood combined with very low general toxicitles and substantially reduced hepatomegalitic effects.

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