C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A61K 31/40 (2006.01) A61K 38/00 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07D 487/22 (2006.01) C07F 1/08 (2006.01) C07F 3/00 (2006.01) C07K 14/00 (2006.01) C07K 14/685 (2006.01) C07K 14/795 (2006.01) C07K 16/00 (2006.01) C12N 9/18 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2101227
Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention.The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain. The conjugates are fox use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell- specific ligands, such as hormones, growth factors or tumor- specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.
Fiedor Leszek
Salomon Yoram
Scherz Avigdor
Borden Ladner Gervais Llp
Fiedor Leszek
Salomon Yoram
Scherz Avigdor
Yeda Research And Development Co. Ltd.
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