C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/22 (2006.01) A61K 31/40 (2006.01) A61K 31/555 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01) A61P 33/00 (2006.01) C07D 209/00 (2006.01) C07D 257/00 (2006.01) C07H 13/04 (2006.01) C07H 13/10 (2006.01) C07H 15/26 (2006.01) C07K 14/795 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2392989
Novel C-132-COXR1, C-172-COXR2 and C-132-COXR1, C-172-COXR1 derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R1 and R2 , the same or different, may be an optionally substituted hydrocarbyl , amino acid, peptide, protein or saccharide radical. The compounds are for use in photodynamic therapy (PDT), for diagnosis of tumors, and for killing cells and infectious agents such as bacteria and virus, both in biological products and in living tissues.
La présente invention concerne de nouveaux dérivés de composés chlorophylle et bactériochlorophylle C-13?2¿-COXR¿1?, C-17?2¿-COXR¿2?, C-13?2¿-COXR¿1?, et C-17?2¿-COXR¿1?, dans lesquels X représente O, S ou N et R¿1? et R¿2?, identiques ou différents, peuvent être un radical hydrocarbyle, acide aminé, peptide, protéine ou saccharide éventuellement substitué. Ces composés sont utilisés en thérapie photodynamique (TPD), dans le diagnostique de tumeurs, et pour tuer les cellules et les agents infectieux, tels que les bactéries et les virus, aussi bien dans les produits biologiques que dans les tissus vivants.
Brandis Alexander
Kammhuber Nina
Salomon Yoram
Scheer Hugo
Scherz Avigdor
Borden Ladner Gervais Llp
Ltd. Yeda Research And Development Co.
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