C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/00 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 38/04 (2006.01) C07D 209/14 (2006.01) C07D 209/18 (2006.01) C07D 209/20 (2006.01) C07D 403/06 (2006.01) C07D 405/02 (2006.01) C07D 417/06 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) C07K 14/595 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2088195
2088195 9204045 PCTABS00011 Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.
Holmes Ann
Horwell David C.
Kleinschroth Jurgen
Padia Janak K.
Rees David C.
Macrae & Co.
Warner-Lambert Company
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