Choline binding proteins for anti-pneumococcal vaccines

Details Choline binding proteins for anti-pneumococcal vaccines Choline binding proteins for anti-pneumococcal vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 38/51 (2006.01) A61K 39/09 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) C12N 5/16 (2006.01) C12N 9/88 (2006.01) C12N 15/60 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2253252

The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.

L'invention concerne des protéines bactériennes fixant la choline (CBPs) qui fixe la choline. De telles protéines sont particulièrement utiles pour les vaccins contres les souches appropriées de bactéries Gram positives, en particulier les streptocoques, et plus particulièrement les pneumocoques. L'invention décrit également des séquences d'ADN codant les protéines de fixation de la choline bactériennes ou un fragment de celles-ci, des anticorps contre des protéines de fixation de la choline bactériennes, des compositions pharmaceutiques comprenant des protéines bactériennes de fixation de la choline, des anticorps contre les protéines bactériennes de fixation de la choline utiles dans l'immunisation passive, et des inhibiteurs de petites molécules de l'adhésion induite par les protéines de fixation de la choline. Des procédés permettant de diagnostiquer la présence d'une protéine de fixation de choline bactérienne, ou des bactéries, sont également décrits. Dans un mode spécifique de réalisation, une protéine de fixation de choline streptococcique est une énolase, ce qui démontre une forte affinité pour la fibronectine.

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