A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61K 31/205 (2006.01) A61P 1/14 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) A61P 15/08 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2431883
The invention relates to choline pyruvate of formula (I) wherein 0 < n <= 10, and is a stabile, physiologically compatible formulation containing said choline pyruvate, water and/or an organic solvent such as glycerine, or is present in a solid and preferably a powder form. The invention also relates to a method for producing choline pyruvate, whereby choline hydroxide is placed in a solvent, such as water or a methanol/water mixture, at a temperature of between 0 and 98 ~C, then pyruvric acid is added drop by drop in external cooling conditions and mixed until a pH value of between 5.0 and 8.0 is reached, the solvent is then removed and finally the obtained product is added to a physiologically compatible solvent. The choline pyruvate or the formulations containing choline pyruvate can be used preferably, as a food additive, as an animal food additive, as dietary substances, for improving general performances in the fields of sport, strength and endurance areas and, in deficiencies and illnesses of the central and/or peripheral nervous system and in the cosmetic field. Said choline pyruvate combines the positive physical and physiological properties of monosubstances such as choline and pyruvic acid and is particularly suitable for various applications in the medical field.
L'invention concerne la choline-pyruvate de la formule (I) dans laquelle 0 < n <= 10, ainsi qu'une formulation stable physiologiquement acceptable contenant cette choline-pyruvate, et de l'eau et/ou un solvant organique tel que la glyc~rine, ladite formulation ~tant pr~sente ~ l'~tat solide, de pr~f~rence ~ l'~tat pulv~rulent. L'invention concerne ~galement un proc~d~ de fabrication de choline-pyruvate consistant ~ mettre en oeuvre du choline-hydroxyde ~ des temp~ratures de 0 ~ 98~C dans un solvant tel que l'eau ou un m~lange m~thanol/eau, ~ additionner au goutte ~ goutte de l'acide pyruvique sous chauffage externe et m~lange jusqu'~ obtention de valeurs de pH de 5,0 ~ 8,0, ~ extraire ensuite le solvant, et ~ m~langer ~ventuellement le produit obtenu avec un solvant physiologiquement acceptable. La choline-pyruvate ou la formulation de choline-pyruvate peut de pr~f~rence Útre employ~e en tant qu'additif alimentaire, en tant que compl~ment nutritif animal, en tant que substance di~t~tique, pour l'augmentation des performances sportives en g~n~ral, dans le domaine de la puissance et de la r~sistance, dans le cas de troubles et de maladies du systme nerveux central et/ou p~riph~rique, ainsi que dans le domaine cosm~tique. La choline-pyruvate selon l'invention r~unit les propri~t~s physiques et physiologiques positives de la choline et de l'acide pyruvique en tant que monosubstances, et est par cons~quent particulirement adapt~e ~ diverses applications dans le domaine m~dical.
Jager Ralf
Ortenburger Gunter
Pischel Ivo
Purpura Martin
Degussa Ag
Gowling Lafleur Henderson Llp
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