C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) C12N 5/079 (2010.01)
Patent
CA 2390180
The invention concerns the identification of a novel family of CTL (Choline Transporter Like) genes, in particular hCTL1 and hCTL2, involved in the metabolism and/or transport of choline in cells such as the intestinal tract cells, nervous cells, in particular motoneurons, sensitive neurons, neurons of the nucleus dorsalis of the spinal cord and oligodendrocytes. The invention opens up new prospects in particular for the treatment of familial dysautonomia, and Tangier disease. More generally, the identification of CTL genes enables to develop new strategies for treating diseases of the nervous system, in particular neurodegenerative, demyelenating diseases, particularly Alzheimer disease, Parkinson disease and Huntington disease.
La présente invention concerne l'identification d'une nouvelle famille de gènes CTL (Choline Transporter Like), en particulier de hCTL1 et hCTL2, impliquée dans le métabolisme et/ou le transport de choline dans les cellules telles que les cellules du tractus intestinal, les cellules nerveuses, notamment les motoneurones, les neurones sensitifs, les neurones du noyau dorsal de la moelle épinière et les oligodendrocytes. L'invention ouvre de nouvelles perspectives notamment pour le traitement de la dysautonomie familiale, et de la maladie de Tangier. Plus généralement, l'identification des gènes CTL permet la mise au point de nouvelles stratégies pour le traitement des maladies du système nerveux, notamment des maladies neurodégénératives, démyélinisantes, de préférence la maladie d'Alzheimer, de Parkinson, et de Huntington.
Meunier Francois
O'regan Seana
Ruat Martial
Traiffort Elisabeth
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