Chondrocyte precursors derived from human embryonic stem cells

Details Chondrocyte precursors derived from human embryonic stem cells Chondrocyte precursors derived from human embryonic stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12N 5/077 (2010.01) A61K 35/32 (2006.01) C12Q 1/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2468335

This invention provides a system for obtaining cells of the chondrocyte lineage by differentiating primate pluripotent stem cells. The process involves culturing the cells as a micromass or other aggregate form in a cocktail of differentiation agents that facilitates outgrowth of the desired cell type. Progeny are capable of synthesizing Type II collagen or aggrecan, or other products that are characteristic of the chondrocyte lineage. Chondrocytes and chondrocyte precursor cells obtained according to this disclosure are suitable for use in both research and clinical therapy.

L'invention concerne un système permettant d'obtenir des cellules à partir d'une lignée de chondrocytes par le biais d'une différentiation de cellules souches pluripotentes de primate. Ce procédé consiste à cultiver les cellules en tant que micromasse ou sous une autre forme d'agrégat, dans un cocktail d'agents de différentiation permettant de faciliter la croissance du type de cellule voulu. La descendance permet de synthétiser de l'aggrécan ou du collagène de type II, ou d'autres produits caractéristiques de la lignée de chondrocytes. Les chondrocytes et les cellules précurseurs de chondrocytes obtenus selon l'invention sont adaptés à une utilisation à la fois dans le domaine de la recherche et dans le domaine de la thérapie clinique.

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