C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/51 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2128647
Abstract of the Disclosure A concanavalin A-binding protein found in chondrocytes, but not found in dedifferentiated cells from chondrocytes. This protein preferably has a molecular weight of about 76kD or of about 67 kD after treatment with endoglycosidase according to an analysis by SDS-PAGE and at least one of the amino acid sequences as shown in SEQ ID No:1-5. Said protein is the substance that relates to differentiation of chondrocytes and also to control of functions by chondrocytes and control of cartilaginous osteogenesis, and may be utilized as a new type of therapy, prophylaxis and diagnosis of cartilaginous metabolic diseases and metabolic bone diseases.
Doi Kazuyuki
Kato Yukio
Pan Haiou
Bereskin & Parr
Hoechst Japan Limited
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