Chondrogenic potential of human bone marrow-derived cd105+...

A - Human Necessities – 61 – K

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A61K 38/18 (2006.01)

Patent

CA 2438934

Compositions of BMPs useful for cartilage repair and methods employing these compositions are disclosed. Compositions comprising non-tissue culture expanded cells isolated from bone marrow and treated with BMPs useful for cartilage repair and methods employing these compositions are also disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.

La présente invention concerne, d'une part des compositions à base de protéines BMP (protéines de la morphogenèse osseuse) convenant pour la réparation des cartilages, et d'autre part des procédés permettant d'employer ces compositions. L'invention concerne également des cellules développées par culture non tissulaire, tirées de la moelle osseuse et traitées par les BMP, convenant pour la réparation des cartilages et des procédés permettant d'employer ces compositions. Ces compositions conviennent au traitement de l'arthrose, au traitement des défauts des cartilages, et à la réparation tissulaire s'y rapportant.

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