Chondroprotective agents

Details Chondroprotective agents Chondroprotective agents

A - Human Necessities

61

K

A61K 31/35 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2126513

ABSTRACT OF THE DISCLOSURE A chondroprotective agent comprising a flavonoid compound of the general formula (I): Image (I) wherein R1 to R9 are, independently, a hydrogen atom, hydroxyl group, or methoxyl group and X is a single bond or a double bond, or a stereoisomer thereof, or a naturally occurring glycoside thereof is disclosed. The above compound strongly inhibits proteoglycan depletion from the chondrocyte matrix and exhibits a function to protect cartilage, and thus, is extremely effective for the treatment of arthropathy.

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