Chp polypeptide, a ligand of pak65

Details Chp polypeptide, a ligand of pak65 Chp polypeptide, a ligand of pak65

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2339891

The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signalling and signal transduction pathways, including, e.g. a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, or a Chp-specific immunogenic activity. The invention relates to all aspects of Chp, or homologs thereof, including assays for modulators, activators, ligands, etc.

La présente invention concerne un polypeptide Chp entier isolé, un fragment de polypeptide biologiquement actif de ce dernier, et des acides nucléiques qui codent ce dernier. Ce polypeptide possède différentes activités liées à la régulation des mécanismes de signalisation cellulaire et de transduction du signal, y compris, par exemple, une activité de liaison du domaine de régulation PAK, une activité de stimulation de kinase PAK, une activité de stimulation de kinase JNK, une activité de réorganisation du cytosquelette, ou une activité immunogène à spécificité Chp. L'invention concerne également tous les aspects de Chp, ou des homologues de ce dernier, y compris des dosages destinés à des modulateurs, des activateurs, des ligands et autres.

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