C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/554 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2531768
Haplotypes in the CHRNA2 gene associated with cognitive response to galantamine treatment are disclosed. Compositions and methods for detecting and using these CHRNA2 hyplotypes in a variety of clinical applications are disclosed. Such applications include articles of a manufacture comprising galantamine or derivatives thereof that are approved for treating patients having one of these CHRNA2 haplotypes, methods and kits for predicting the response of an individual to galantamine based upon his/her haplotype profile, and methods for treating Alzheimer~s patients based upon their haplotype profile.
L'invention concerne des haplotypes dans le gène CHRNA2 associé à la réponse cognitive au traitement à la galantamine. Elle concerne également des compositions et des procédés pour détecter et utiliser ces haplotypes CHRNA2 dans diverses applications cliniques. De telles applications englobent notamment des articles manufacturés comprenant la galantamine ou ses dérivés homologués destinés au traitement de patients présentant un de ces haplotypes CHRNA2, des procédés et des trousses permettant de prévoir la réaction d'un patient à la galantamine sur la base de son profil haplotype, ainsi que des procédés permettant de traiter des patients atteints de la maladie d'Alzheimer en fonction de leur profil haplotype.
Aerssens Jeroen
Athanasiou Maria
Brain Carlos
Cohen Nadine
Dain Bradley
Genaissance Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
Pgxhealth Llc
LandOfFree
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