Chroman derivatives

Details Chroman derivatives Chroman derivatives

C - Chemistry, Metallurgy

07

D

C07D 311/72 (2006.01) A61K 31/353 (2006.01)

Patent

CA 2583087

The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I, wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

La présente invention concerne de nouveaux dérivés de chromane, des stéréo-isomères et des sels de ceux-ci répondant aux normes pharmaceutiques, représentés par la formule (I), dans laquelle les substituants sont tels que définis dans les spécifications. Ces composés conviennent pour le traitement de pathologies induites par la lipoxygenase, tels que des maladies immunes, des maladies respiratoires et des maladies cardio-vasculaires ainsi que pour le traitement de pathologies neurodégénératives et/ou de troubles de mitochondriaux. Ces composés conviennent pour la fabrication de préparations pharmaceutiques destinées au traitement de ces pathologies.

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