Chroman derivatives

Details Chroman derivatives Chroman derivatives

C - Chemistry, Metallurgy

07

D

C07D 311/22 (2006.01) C07D 311/58 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2355098

Chroman derivatives of the formula I (see formula I) in which R1 is acyl having 1-6 C atoms, -CO-R5 or an amino protective group, R2 is H or alkyl having 1-6 C atoms, R3, R4 in each case independently of one another are H, alkyl having 1-6 C atoms, CN, Hal or COOR2, R5 is phenyl which is unsubstituted or mono- or disubstituted by alkyl having 1-6 C atoms, OR2 or Hal, X is H,H or O, Hal is F, Cl, Br or I, and their salts, are suitable as intermediates in the synthesis of medicaments.

L'invention concerne des dérivés de chromane de formule (I), ainsi que leurs sels. Dans la formule, R<1> représente acyle comportant 1 à 6 atomes de C, -CO-R<5> ou un groupe protégeant un groupe amino; R<2> représente H ou alkyle comportant 1 à 6 atomes de C; R<3>, R<4> représentent indépendamment l'un de l'autre H, alkyle comportant 1 à 6 atomes de C, CN, Hal ou COOR<2>; R<5> représente phényle non substitué ou substitué une ou deux fois par alkyle comportant 1 à 6 atomes de C, par OR<2> ou par Hal; X représente H, H ou O; Hal représente F, Cl, Br ou I. Ces dérivés s'utilisent comme produits intermédiaires pour la synthèse de médicaments.

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