Chroman derivatives

Details Chroman derivatives Chroman derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/44 (2006.01) A61K 31/695 (2006.01) C07D 405/14 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2070243

ABSTRACT OF THE DISCLOSURE A chroman derivative represented by the following general formula [1]: Image [1] wherein R1 represents cyano group, nitro group, halogenomethyl group or -SO2-X group (X represents lower alkyl group having 1-6 carbon atoms or aryl group); R2 represents hydrogen atom or OA group (A represents hydrogen atom, nitro group, lower acyl group having 1-6 carbon atoms, arylcarbonyl group, lower alkylsulfonyl group having 1-6 carbon atoms, arylsulfonyl group, arylalkyl group, tetrahydropyranyl group, lower alkoxycarbonyl group having 1-6 carbon atoms, arylalkoxy- carbonyl group or silyl derivative group); R3 singly represents a hydrogen atom; or R3 forms a bond jointly with R2; and R4, R5, R6 and R7 each represent hydrogen atom, vinyl group, formyl group, -Y-(OA)n group (Y represents straight or branched chain alkylene group having 1-6 carbon atoms or lower alkenyl group having 1-6 carbon atoms, A is as defined above, and n represents an integer of 1-3, provided that when n is 2 or greater, each OA groups are identical or independent of one another) or -CO-Z group (Z represents hydrogen atom, lower alkyl group having 1-6 carbon atoms, aryl group, hydroxyl group or lower alkoxy group having 1-6 carbon atoms); provided that R4, R5, R6 and R7 are identical or independent of one another. The compound of this invention is expected to be effectively usable as an agent for prevention and treatment of various symptoms due to the contraction of smooth muscles, for prevention and treatment of the diseases of the circulatory system and for prevention and treatment of epilepsy.

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