C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/58 (2006.01) A61K 31/352 (2006.01)
Patent
CA 2506238
A compound of the general formula (I): (see formula I) wherein R1 is hydrogen, alkyl, cycloalkyl or C(O)R7, R2 and R3 are independently hydrogen, hydroxy, alkoxy, alkyl, cycloalkyl, halo or OC(O)R7, with the exception that R2 and R3 are not both hydrogen, R4, R5 and R6 are independently hydrogen, hydroxy, alkoxy, alkyl, cycloalkyl, acyl, NH2, NHC1-C4 alkyl or N(C1-C4 alkyl)2, OC(O)R7 or OR8, R7 is hydrogen, alkyl, cycloalkyl, aryl, arylalkyl or amino, R8 is aryl such as phenyl or arylalkyl such as benzyl, and Rx is hydrogen hydroxy, alkoxy, alkyl, cycloalkyl or halo or a pharmaceutically acceptable salt or derivative thereof, compositions comprising same, processes for preparing said compounds and compositions. The invention also extends to use of said compounds and compositions particularly in therapy such as in the treatment of cancer.
Heaton Andrew
Husband Alan
Marshall Edwards Inc.
Novogen Research Pty Ltd
Smart & Biggar
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