Chromane derivatives as trpv3 modulators

C - Chemistry – Metallurgy – 07 – D

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C07D 311/04 (2006.01)

Patent

CA 2728405

The present invention provides chromane derivatives as transient receptor potential vanilloid (TRPV) modulators. In particular, the compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

La présente invention concerne des dérivés de chromane en tant que modulateurs des potentiels récepteurs transitoires vanilloïdes (TRPV). En particulier, les composés décrits ici sont utiles pour traiter ou prévenir des maladies, des états et/ou des affections modulés par TRPV3. L'invention concerne également des procédés de préparation des composés décrits ici, des intermédiaires utilisés dans leur synthèse, des compositions pharmaceutiques les contenant, et des procédés pour traiter ou prévenir des maladies, états et/ou affections modulés par TRPV3.

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