Chromane substituted benzimidazoles and their use as acid...

Details Chromane substituted benzimidazoles and their use as acid... Chromane substituted benzimidazoles and their use as acid...

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4184 (2006.01) A61P 1/04 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2631880

This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein X is O or NH, and -A-B- is -0-CH2-, -CH2-O-, - S-CH2- or -CH2-S- or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds In the treatment of a condition mediated by acid pump antagonistic activity such as; but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID- induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non- erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivatio.pi., airway disorders or asthma.

Cette invention concerne des composés de formule (I) : ou un sel pharmaceutiquement acceptable de ceux-ci, X représentant O ou NH et -A-B- représentant -O-CH2-, -CH2-O-, -S-CH2- ou -CH2-S- ou un sel pharmaceutiquement acceptable, ainsi que des compositions contenant de tels composés et l~utilisation de tels composés pour le traitement d~un état induit par l~activité antagoniste de la pompe à protons tel que, mais sans y être limité, une maladie gastro-intestinale, une maladie gastro-AEsophagienne, un reflux gastro-AEsophagien (RGO), un ulcère gastro-duodenal, un ulcère gastrique, un ulcère duodénal, des ulcères induits par AINS, une gastrite, une infection d~Helicobacter pylori, une dyspepsie, une dyspepsie fonctionnelle, le syndrome de Zollinger-Ellison, une maladie de reflux non inflammatoire (NERD), une douleur viscérale, un pyrosis, une nausée, une AEsophagite, une dysphagie, une hypersalivation, des troubles des voies respiratoires ou de l~asthme.

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