Chromatographic separation of therapeutic polypeptides

C - Chemistry – Metallurgy – 07 – K

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C07K 1/16 (2006.01)

Patent

CA 2538183

The present invention is directed to the purification and commercialization of therapeutic polypeptides that have. In one aspect of the invention, a method of purifying Interferon .beta.-1b using size exclusion chromatography is provided. In another aspect of the invention, a method of purifying a polypeptide using size chromatography is provided. A third aspect provides a method of commercializing a polypeptide.

L'invention concerne la purification et la commercialisation de polypeptides présentant une valeur thérapeutique avérée. Un aspect de la présente invention concerne un procédé de purification d'Interféron .beta.-1b mettant en oeuvre la chromatographie d'exclusion diffusion. Un autre aspect de l'invention concerne un procédé de purification d'un polypeptide par chromatographie d'exclusion diffusion. Un troisième aspect de l'invention concerne un procédé de commercialisation de ces polypeptides.

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