Chromatographic separation process

B - Operations – Transporting – 01 – D

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B01D 15/08 (2006.01) C13B 20/14 (2011.01) B01D 15/18 (2006.01) B01D 15/36 (2006.01) B01J 39/26 (2006.01) B01J 47/02 (2006.01) C07H 1/06 (2006.01)

Patent

CA 2345802

A chromatographic separation process of a type wherein a feedstock fluid containing a plurality of components is supplied into a circulative chromatographic separation system, the process comprising the steps of (i) supplying the feedstock fluid and withdrawing a fraction enriched in a component, (ii) supplying a desorbent fluid and withdrawing a fraction enriched in another component, and (iii) circulating the fluid through the bed without supplying or withdrawing any fluid thereby making a mixed zone comprising a plurality of components move, a cycle including steps (i), (ii) and (iii) being repeated, wherein the packed bed comprises a first unit bed packed with an adsorbent, to which the feedstock fluid is supplied, and at least one other unit bed packed with an adsorbent, and the adsorbent (e.g., ion-exchange resin) packed into the first unit bed, to which the feedstock fluid is supplied, has a greater average particle size and/or a higher degree of crosslinking than that packed in the at least one other unit packed bed.

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