Chromene or thiochromene derivatives, process for preparing...

Details Chromene or thiochromene derivatives, process for preparing... Chromene or thiochromene derivatives, process for preparing...

C - Chemistry, Metallurgy

07

D

167/242, 167/244

C07D 311/70 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) C07D 311/58 (2006.01) C07D 311/96 (2006.01) C07D 335/06 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2026389

- 1 - Abstract The present invention is directed to chromene or thiochromene derivatives of the formula: Image (I) wherein A is an oxygen or sulfur atom, R1 is a halogenophenyl, R2 and R3 are the same or different and each represent a lower alkyl or R2 and R3 are combined together to form -(CH2)n- in which n is an integer of 4 to 6, or a pharmaceutically acceptable ester, amide, lactone or salt thereof. Such derivatives have excellent HMG-CoA reductase inhibitory activity and are useful for the prophylaxis and treatment of hyperlipidemic diseases. The invention further provides a process for preparing said compound and an intermediate compound used for preparing said compound.

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