C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/242, 167/244
C07D 311/70 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) C07D 311/58 (2006.01) C07D 311/96 (2006.01) C07D 335/06 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2026389
- 1 - Abstract The present invention is directed to chromene or thiochromene derivatives of the formula: Image (I) wherein A is an oxygen or sulfur atom, R1 is a halogenophenyl, R2 and R3 are the same or different and each represent a lower alkyl or R2 and R3 are combined together to form -(CH2)n- in which n is an integer of 4 to 6, or a pharmaceutically acceptable ester, amide, lactone or salt thereof. Such derivatives have excellent HMG-CoA reductase inhibitory activity and are useful for the prophylaxis and treatment of hyperlipidemic diseases. The invention further provides a process for preparing said compound and an intermediate compound used for preparing said compound.
Nakai Hideo
Nomura Sumihiro
Suzuki Kazuko
Takashima Kohki
Yamada Koichiro
Kirby Eades Gale Baker
Nakai Hideo
Nomura Sumihiro
Suzuki Kazuko
Takashima Kohki
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