C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/22 (2006.01) A61K 31/353 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2738794
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
L'invention concerne de nouveaux composés modulateurs de sirtuine et leurs méthodes dutilisation. Les composés modulateurs de sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et pour traiter et/ou prévenir une large variété de maladies et de troubles comprenant, par exemple, des maladies ou troubles associés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des troubles de coagulation du sang, une inflammation, le cancer et/ou des bouffées congestives ainsi que des maladies ou des troubles qui bénéficieraient d'une activité mitochondriale accrue. L'invention concerne également des compositions contenant un composé modulateur de sirtuine associé à un autre agent thérapeutique.
Oalmann Christopher
Perni Robert B.
Vu Chi B.
Gowling Lafleur Henderson Llp
Sirtris Pharmaceuticals Inc.
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