C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/353 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/4433 (2006.01) A61P 9/00 (2006.01) C07D 311/22 (2006.01)
Patent
CA 2348391
The invention relates to compounds having formula (I), wherein R1, R2, R3, R4, R5, R7, R8, R11, Z, m and n have the meaning cited in claim 1, and to the physiologically acceptable salts and solvates which can be used as integrin inhibitors, especially in the prophylaxis and treatment of circulatory diseases, in case of thrombosis, myocardial infarction, coronary heart diseases, arteriosclerosis, osteoporosis, pathologic processes caused or propagated by angiogenesis and in tumor therapy.
L'invention concerne des composés de la formule (I) dans laquelle R<1>, R<2>, R<3>, R<4>, R<5>, R<7>, R<8>, R<11>, Z, m et n ont la signification mentionnée dans la revendication 1. L'invention concerne en outre leurs sels et solvates physiologiquement tolérables. Ces composés, leurs sels et solvates s'utilisent comme inhibiteurs d'intégrine, notamment pour assurer la prophylaxie et le traitement d'affections de la circulation, en cas de thrombose, d'infarctus, de maladies cardiaques coronaires, d'artériosclérose, d'ostéoporose, en cas de processus pathologiques entretenus ou propagés par angiogenèse et dans le traitement de tumeurs.
Fittschen Claus
Goodman Simon
Marz Joachim
Raddatz Peter
Wiesner Matthias
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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