Chromenone derivatives as trpv3 antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 311/08 (2006.01)

Patent

CA 2743276

The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRP V3. (Formula I) (I)

La présente invention concerne des modulateurs des récepteurs transitoires à potentiel vanilloïde (TRPV) représentés par la formule (I). En particulier, les composés de l'invention conviennent au traitement ou à la prévention de maladies, d'états et/ou de troubles modulés par TRPV3. L'invention concerne également des procédés pour l'élaboration des composés de l'invention, des intermédiaires utilisés pour leur synthèse, des compositions pharmaceutiques les utilisant, et des procédés permettant de traiter ou de prévenir des maladies, des états et/ou des troubles modulés par TRPV3.

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