Chromogenic enzyme substrates

Details Chromogenic enzyme substrates Chromogenic enzyme substrates

C - Chemistry, Metallurgy

12

Q

530/5.04

C12Q 1/56 (2006.01) C07K 5/093 (2006.01) C07K 5/103 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 1048998

Abstract of the Disclosure New chromogenic substrates for serine proteases, specially suitable for diagnostic determination of factor Xa, which are represented by the following general formula: R1-A1-A2-Gly-Arg-NH-R2 or its salts, where R1 may be selected from hydrogen, alkanoyl having from 1 to 12 carbon atoms, cyclohexylcarbonyl, benzoyl, benzoyl substituted with e.g. one or two halogen atoms, methylamino or phenyl groups, benzene sulphonyl and toluenesulphonyl, R2 may be selected from nitrophenyl, naphthyl, nitro- naphthyl, methoxynaphthyl, quinolyl and nitroquinolyl, A1 may be selected from a single bond, or the amino acids Gly, Ala, Val, Leu, Ileu, Pro, Met, Phe and Tyr, and A2 may be selected from the amino acids Glu, Gln, Asp, Asn.

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