C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/203 (2006.01) C07H 15/26 (2006.01) C07H 17/02 (2006.01) C07H 17/075 (2006.01) C12N 9/24 (2006.01) C12Q 1/34 (2006.01)
Patent
CA 2382830
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
La présente invention concerne la conception, la synthèse, et l'évaluation biochimique de composés substratiques chromogéniques de sialidases d'origine bactérienne, virale, protozoaire, et vertébrée (origine humaine comprise). Cette invention concerne en particulier une classe de composés efficaces en tant que substrats chromogéniques de ces sialidases produisant des produits chromogéniques après déroulement des réactions catalysées par les sialidases. L'invention concerne également des procédés de fabrication de ces composés substratiques, et des procédés de diagnostic et de pronostic de maladies liées aux salidases, utilisant ces composés substratiques.
Johnson Stephen C.
Luo Ming
Yan Shijia
Ibbex Inc.
Macrae & Co.
Uab Research Foundation
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