Chromone derivatives

Details Chromone derivatives Chromone derivatives

C - Chemistry, Metallurgy

07

D

260/357.5, 260/3

C07D 311/24 (2006.01) C07C 45/54 (2006.01) C07C 45/62 (2006.01) C07C 45/63 (2006.01) C07C 45/64 (2006.01) C07C 45/67 (2006.01) C07C 45/71 (2006.01) C07C 49/83 (2006.01) C07C 49/86 (2006.01) C07D 311/58 (2006.01) C07D 311/74 (2006.01) C07D 311/78 (2006.01) C07D 311/92 (2006.01) C07D 493/04 (2006.01)

Patent

CA 1065329

ABSTRACT There are described compounds of formula I, Image I in which R3 represents hydrogen, or alkyl C 1 to 6, R5 represents hydrogen, hydroxy, alkoxy C 1 to 6, alkanoyloxy C 2 to 6, alkenyloxy C 2 to 6, nitro, -NR1R2, halogen, alkyl C 1 to 6,hydroxy-alkyl C 1 to 6, or hydroxy-alkoxy C 1 to 6, an adjacent pair of X, Y and Z form a -(CH2)4-, -CH=CH-CH=CH- or -O(CH2)3- chain, each of the chains optionally being substituted by one or two C 1 to 6 alkyl groups, and the remaining substituent X or Z represents alkenyl C 2 to 6 optionally substituted by phenyl; halogen; or alkyl C 1 to 9 optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy C 1 to 6, or, when an adjacent pair of X, Y and Z form a chain substituted by one or two C 1 to 6 alkyl groups, the remaining substituent X or Z may be hydrogen, and R1 and R2, which may be the same or different, are each hydrogen or alkyl C 1 to 6, and pharmaceutically acceptable derivatives thereof. Processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds are also described.

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