Chromosome 3, 5 and 11 genes involved in premature canities

Details Chromosome 3, 5 and 11 genes involved in premature canities Chromosome 3, 5 and 11 genes involved in premature canities

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61Q 5/00 (2006.01)

Patent

CA 2491235

The invention concerns the use of at least one polynucleotide fragment comprising at least 18 consecutive nucleotides whereof the sequence corresponds to all or part of a human chromosome 3 gene selected among KIAA1042, CCK, CACNA1D, ARHGEF3 and AL133097 or whereof the sequence corresponds to all or part of a human chromosome 5 gene selected among KLHL3, HNRPAO, CDC25C, EGR1, C5orf6, C5orf7, LOC51308, ETF1, HSPA9B, PCDHAI to PCDHA13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, C5orf3, MFAP3, GALNTIO and FLJ11715 genes, or whereof the sequence corresponds to all or part of a human chromosome 11 gene selected among GUCYIA2, CULS, ACAT1, NPAT, ATM, AF035326, AF035327, AF035328, BC029536, FLJ20535, DRD2, ENS303941, IGSF4, LOC51092, BC010946, TAGLN, PCSK7 and ENS300650 genes, the use of agents capable of modifying the function attached to one said regions, the use of expression products of one of said regions and the use of agents capable of modifying the function of said expression products, for cosmetic, therapeutic or diagnostic applications.

Utilisation d'au moins un fragment polynucléotidique comprenant au moins 18 nucléotides consécutifs dont la séquence correspond à tout ou partie d'un gène du chromosome 3 humain choisi parmi les gènes KIAA1042, CCK, CACNAID, ARHGEF3 et AL133097, ou dont la séquence correspond à tout ou partie d'un gène du chromosome 5 humain choisi parmi les gènes KLHL3, HNRPAO, CDC25C, EGR1, C5orf6, C5orf7, LOC51308, ETF1, HSPA9B, PCDHAI à PCDHA13, CSF1R, RPL7, PDGFRB, TCOF1, AL133039, CD74, RPS14, NDST1, G3BP, GLRA1, C5orf3, MFAP3, GALNTIO et FLJ11715, ou dont la séquence correspond à tout ou partie d'un gène du chromosome 11 humain choisi parmi les gènes GUCYIA2, CULS, ACAT1, NPAT, ATM, AF035326, AF035327, AF035328, BC029536, FLJ20535, DRD2, ENS303941, IGSF4, LOC51092, BC010946, TAGLN, PCSK7 et ENS300650, utilisation d'agents capables de modifier la fonction attachée à l'une de ces régions, utilisation des produits d'expression de l'une de ces régions et utilisation d'agents capables de modifier la fonction de ces produits d'expression, à des fins cosmétiques, thérapeutiques ou diagnostiques.

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