Chromosome 6 and 9 genes involved in premature canities

Details Chromosome 6 and 9 genes involved in premature canities Chromosome 6 and 9 genes involved in premature canities

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61Q 5/10 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2491223

The invention concerns the use of at least one polynucleotide fragment comprising 18 consecutive nucleotides whereof the sequence corresponds to all or part of a human chromosome 6 gene selected among the HLAG, NT_¿_?007592.445, NT_007592.446, NT_007592.506, NT_007592.507, NT_007592.508, HSPAIB, G8, NEU1, NG22, BAT8, HLA-DMB, HLA-DMA, BRD2, HLA-DQA1, HLA-DQA2, NT_007592.588, GRM4, RNF23, FLJ22638, NT_007592.459 and NT_007592.457 genes, or whereof the sequence corresponds to all or part of the human chromosome 9 gene selected among the FREQ, NT_030046.18, NT_030046.17, GTF3C5, CEL, CELL, FS, ABO, BARHL1, DDX31, GTF3C4 and Q96MA6 genes, the use of agents capable of modifying the function attached to one of said genes, the use of expression products of one of said genes and use of agents capable of modifying the function of said expression products, for cosmetic, therapeutic or diagnostic applications.

Utilisation d'au moins un fragment polynucléotidique comprenant au moins 18 nucléotides consécutifs dont la séquence correspond à tout ou partie d'un gène du chromosome 6 humain choisi parmi les gènes HLAG, NT__007592.445, NT_007592.446, NT_007592.506, NT_007592.507, NT_007592.508, HSPAIB, G8, NEU1, NG22, BAT8, HLA-DMB, HLA-DMA, BRD2, HLA-DQA1, HLA-DQA2, NT_007592.588, GRM4, RNF23, FLJ22638, NT_007592.459 et NT_007592.457, ou dont la séquence correspond à tout ou partie d'un gène du chromosome 9 humain choisi parmi les gènes FREQ, NT_030046.18, NT_030046.17, GTF3C5, CEL, CELL, FS, ABO, BARHL1, DDX31, GTF3C4 et Q96MA6, utilisation d'agents capables de modifier la fonction attachée à l'un de ces gènes, utilisation des produits d'expression de l'un de ces gènes et utilisation d'agents capables de modifier la fonction de ces produits d'expression, à des fins cosmétiques, thérapeutiques ou diagnostiques.

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