Chromosome specific staining to detect genetic rearrangements

Details Chromosome specific staining to detect genetic rearrangements Chromosome specific staining to detect genetic rearrangements

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2060267

-97- CHROMOSOME-SPECIFIC STAINING TO DETECT GENETIC RE~RRANGE~ENTS ~STRACT OF_THE DISCLOSURE Provided ar~ methods and compositions ~or stainlng chromosomal material based upon nucleic acid se~uence employing high complexity nucleic acid probes ~herein t:he staining pattern produced is indicative of the presence or absence of one or more genetic rearrangements involvlng chromosomes 3, 13 and/or 17. Said probes are appropriate for in situ hybridi~ation and stain both int~rphase and metapha~e chromosomal material with reliable signals. The staining methods can be used in conjunction with digital image analysi~. Probes and test kits are provided ~or use in detecting genetic rearrangements, particularly those related to tumor suppre~sor genes~ in the detection of disPase related loci, specifically cancer, such as retinoblastomas, ost~osarcomas, lung cancer, breast cancer, oYarian and uterine cancers, and for biologica} dosimetry. Re~erence probes, for ~xample, centromeric alph~ satellite probes, can be a component of the high complexity probes.

Affiliated with

Also associated with

Rating

Chromosome specific staining to detect genetic rearrangements does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chromosome specific staining to detect genetic rearrangements, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromosome specific staining to detect genetic rearrangements will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1660533