Chronotherapeutic compositions and methods of their use

Details Chronotherapeutic compositions and methods of their use Chronotherapeutic compositions and methods of their use

A - Human Necessities

61

K

A61K 9/00 (2006.01)

Patent

CA 2556220

Chronothrapeutic formulations of cardiovascular drugs are disclosed. The formulations comprise at least one cardiovascular drug that exhibits an in vivo elimination half-life of less than about 8 hours; wherein the formulation exhibits the following in vivo profile following administration to a subject: a) a delay in release of therapeutic levels of the at least one drug for about 2 to about 8 hours; b) a Tmax at about 8 to about 12 hours; c) a drug plasma level within 50% of the peak for greater than or equal to 12 hours; and d) a peak-to-trough ratio of drug plasma levels greater than or equal to about 4.

L'invention concerne des compositions chronothérapeutiques de médicaments cardiovasculaires. Les formulations de l'invention comprennent au moins un médicament cardiovasculaire qui possède une demi-vie d'élimination in vivo inférieure à environ 8 heures, la formulation présentant le profil in vivo suivant après avoir été administrée à un sujet : a) un retard dans la libération des niveaux thérapeutiques d'au moins un médicament compris entre environ 2 et environ 8 heures ; b) a T¿max? se produisant entre environ 8 et environ 12 heures ; c) un niveau plasmatique de médicament inférieur à 50 % du pic pour les périodes supérieures ou égales à 12 heures ; et d) un rapport pic à creux des niveaux plasmatiques de médicament supérieur ou égal à 4 environ.

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