Chrysospermins, active peptides from apiocrea chrysosperma...

Details Chrysospermins, active peptides from apiocrea chrysosperma... Chrysospermins, active peptides from apiocrea chrysosperma...

C - Chemistry, Metallurgy

12

P

C12P 21/02 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C12N 1/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2115966

Abstract of the Disclosure Chrysospermins, active peptides from Apiocrea chryso- sperma having a pharmacological effect, a process for their preparation and the use thereof The invention relates to the chrysospermin active peptides of the formula I AcPhe-Aib-Ser-Aib-x-Leu-Gln-Gly-Aib-Aib-Ala-Ala-Alb-Pro- y-Aib-Aib-Gln-Trp-ol in which x and y, independently of each other, denote Aib or Iva, which are synthesized by the fungus Apiocrea chrysosperma during fermentation and which accumulate in the culture broth, to a preparation process, to the use of the chrysospermins as pharmacological active compounds, in particular as active compounds against bacteria, fungi and/or nematodes, and for the treatment of rejection reactions in organ transplantations and of tumor disorders, and to the microorganism Apiocrea chrysosperma DSM 7444.

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