A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4355 (2006.01) A61K 31/436 (2006.01)
Patent
CA 2674367
Embodiments of the present invention are related to novel therapeutic drugs, drug combinations, and associated methods for treating or preventing pulmonary disease, including pulmonary hypertension, pulmonary fibrosis, asthma and COPD, and heart failure, together with other pulmonary and cardiovascular diseases and their complications. More particularly, aspects of the present invention are related to the use of cicletanine and ruboxistaurin as monotherapies or in combination with other agents for treatment of disease. Cicletanine may be used as pure (+) or (-) enantiomers or as a racemic or non-racemic mixture of those enantiomers.
Dans des modes de réalisation, l'invention concerne de nouveaux médicaments thérapeutiques, des combinaisons de médicaments, et des méthodes associées pour traiter ou prévenir les maladies pulmonaires, notamment, l'hypertension pulmonaire, la fibrose pulmonaire l'asthme, la broncho-pneumopathie obstructive chronique (COPD) et l'insuffisance cardiaque, ainsi que d'autres maladies pulmonaires et cardio-vasculaires et leurs complications. Des aspects de l'invention concernent, plus particulièrement, l'utilisation de la ciclétanine et de la ruboxistaurine en monothérapie ou combinées avec d'autres agents pour traiter une maladie. La ciclétanine peut être utilisée sous forme d'éniantomères purs (+) ou (-) ou sous forme de mélanges racémiques ou non racémiques de ces éniantomères.
Cornett Glenn V.
Jones Wayne A.
Page James
Page Karen
Cornett Glenn V.
Jones Wayne A.
Page James
Page Karen
Robic
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