C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 167/44,
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 16/22 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2040404
ABSTRACT OF THE DISCLOSURE The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the invention, the nucleic acid sequences, proteins, and peptides of the invention may be used in the treatment of a variety of neurological diseases and disorders, including Alzheimer's disease. In a specific embodiment of the invention, CNTF may be used to support the growth of spinal cord neurons, thereby providing a method of treating spinal cord damage caused by trauma infarction, infection, nutritional deficiency or toxic agents. The present invention also relates to a novel method for producing substantially pure CNTF. The invention also relates to pharmacuetical compositions comprising effective amounts of CNTF gene products which may be used in the diagnosis and treatment of a variety of neurological diseases and disorders. The present invention relates to the cloning sequencing and expression of CNTF and provides, for the first time, a means for producing human CNTF utilizing human CNTF- encoding nucleic acid sequences. Furthermore, the CNTF nucleic acid sequences of the invention may be utilized to identify nucleic acid sequences encoding CNTF or CNTF- homologous molecules in a variety of species and tissues.
Arakawa Yoshihiro
Carroll Patrick D.
Furth Mark E.
Gotz Rudolf G.
Ip Nancy
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.v.
Osler Hoskin & Harcourt Llp
Regeneron Pharmaceuticals Inc.
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