Cilostazol preparation

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4709 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2368626

Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.

La présente invention concerne une préparation au cilostazol pour laquelle on incorpore une fine poudre de cilostazol dans un agent dispersant et/ou solubilisant de façon à en augmenter la dispersabilité et/ou la solubilité. L'invention concerne également un procédé permettant d'augmenter l'absorbabilité d'un médicament faiblement soluble tel que le cilostazol, même dans la partie inférieure des voies digestives. En effet, ce médicament est difficile à absorber dans la partie inférieure des voies digestives lorsqu'on utilise le procédé conventionnel. Selon l'invention, le cilostazol s'absorbe en quantité suffisante, même dans la partie inférieure des voies digestives, pour avoir une action en tant que thrombolytique, et que médicament améliorant la circulation cérébrale, ou analogue.

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