C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/40 (2006.01) A61K 31/4406 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2352509
Cinnamamide derivatives represented by general formula (I); and immunomodulators and preventive and therapeutic agents for nephrotic syndrome, circulatory disturbance and respiratory diseases, containing the same, wherein R1 is hydroxyl, C1-C6 alkoxy, arylalkoxy or (substituted) amino; R2 and R3 are each halogeno or C1-C4 alkyl; R4 is hydrogen or C1-C6 alkyl; R5 is hydrogen, C1-C6 alkyl or aryl; R6 is hydrogen, C1-C6 alkyl, cyano or C1-C6 alkoxycarbonyl; W is O, S, imino, methylene, hydroxymethylene or carbonyl; X and Y are each O or S; m is an integer of 0 to 2; and n is an integer of 1 to 3, or alternatively the -C(R2)(R3)-W- group may be vinylene when m is 0.
L'invention concerne des dérivés de cinnamamide représentés par la formule générale (I), ainsi que des immunomodulateurs et des agents préventifs et thérapeutiques utiles pour le traitement du syndrome néphrotique, des troubles circulatoires et des maladies respiratoires, qui renferment les dérivés en question. Dans ladite formule, R?1¿ est hydroxyle, alcoxy C¿1-6?, arylalcoxy ou amino (substitué); R?2¿ et R?3¿ sont chacun halogéno ou alkyle C¿1-4?; R?4¿ est hydrogène ou alkyle C¿1-6?; R?5¿ est hydrogène, alkyle C¿1-6? ou aryle; R?6¿ est hydrogène, alkyle C¿1-6?, cyano ou alcoxycarbonyle C¿1-6?; W est O, S, imino, méthylène, hydroxyméthylène ou carbonyle; X et Y sont chacun O ou S; m est un entier compris entre 0 et 2; et n est un entier compris entre 1 et 3, ou bien encore le groupe -C(R?2¿)(R?3¿)-W- peut être vinylène lorsque m vaut 0.
Hasegawa Yoshihiro
Hattori Tomohisa
Hayakawa Hiroyuki
Horiuchi Fumiko
Kumazawa Hiroaki
Smart & Biggar
Tsumura & Co.
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