Cinnamide and hydrocinnamide derivatives with raf-kinase...

Details Cinnamide and hydrocinnamide derivatives with raf-kinase... Cinnamide and hydrocinnamide derivatives with raf-kinase...

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61P 35/00 (2006.01) C07D 213/68 (2006.01) C07D 213/73 (2006.01) C07D 213/79 (2006.01) C07D 231/18 (2006.01) C07D 233/70 (2006.01) C07D 237/24 (2006.01) C07D 239/34 (2006.01) C07D 241/44 (2006.01) C07D 261/12 (2006.01) C07D 277/64 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2594860

The present invention provides novel cinnamide compounds of formula (I) useful as inhibitors of raf -protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and use thereof in the treatment of various cell proliferative diseases, wherein the rings B and C, G and L are as defined herein.

L'invention concerne de nouveaux composés de cinnamide de formule (I) utiles en tant qu'inhibiteurs de Raf protéines kinases. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et des méthodes d'utilisation des compositions susmentionnées pour traiter des maladies prolifératives cellulaires variées. Dans cette formule, les anneaux B et C, G1et L1 sont définis dans la description.

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