Cinnamide derivatives as kcnq potassium channel modulators

Details Cinnamide derivatives as kcnq potassium channel modulators Cinnamide derivatives as kcnq potassium channel modulators

C - Chemistry, Metallurgy

07

C

C07C 237/20 (2006.01) A61K 31/165 (2006.01) A61K 31/33 (2006.01) C07C 233/11 (2006.01) C07C 235/34 (2006.01) C07D 209/08 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 215/04 (2006.01) C07D 215/12 (2006.01) C07D 217/06 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 265/30 (2006.01) C07D 265/36 (2006.01) C07D 295/135 (2006.01) C07D 307/79 (2006.01) C07D 311/58 (2006.01) C07D 311/74 (2006.01) C07D 317/58 (2006.01) C07D 317/60 (2006.01) C07D 319/08 (2006.01) C07D 319/18 (2006.01) C07D 3

Patent

CA 2448894

There is provided novel cinnamide derivatives of Formula I wherein R is C1-4 alkyl or trifluoromethyl, R1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.

L'invention porte sur de nouveaux dérivés de la cinnamide de formule (I) dans laquelle: R est C¿1-4? alkyle ou trifluorométhyle, R?1¿ est choisi parmi pyridinyle, quinolinyle, thiényle, furanyle, 1,4-benzodioxanyle, 1,3-benzodioxolyle, chromanyle, indanyle, biphénylyle, phényle et phényle substitué, qui sont des ouvreurs des canaux potassiques KCNQ, et servent au traitement de troubles répondant à l'ouverture desdits canaux.

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