Cinnamoyl-piperazine derivatives and their use as par-1...

Details Cinnamoyl-piperazine derivatives and their use as par-1... Cinnamoyl-piperazine derivatives and their use as par-1...

C - Chemistry, Metallurgy

07

D

C07D 295/18 (2006.01) A61K 31/4965 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2655527

The present invention relates to compounds of general formula (I), wherein: R1 represents halogen, CN or NO2; R2 represents hydrogen or halogen; n represents 1 or 2; R3 represents phenyl substituted by one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (par-1) antagonists, particularly in the treatment of thrombosis.

L'invention concerne des composés de la formule générale (I), dans laquelle R1 représente: halogène, CN ou NO2; R2 représente: hydrogène ou halogène; n représente: 1 ou 2; R3 représente: phényle substitué par un ou plusieurs halogènes ou C1-C6 alkyle; ou un cyclohexyle; et des sels ou solvates thérapeutiquement acceptables de ces derniers. Les composés de l'invention sont utilisés comme antagonistes du récepteur 1 activé par la protéase ("protease-activated receptor-1" ou PAR-1), en particulier dans le traitement de la thrombose.

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