C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/28 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61P 3/10 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 405/04 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2643044
The present invention is directed to cinnoline and quinazoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.
La présente invention concerne des composés de cinnoline et de quinazoline de formule (I) constituant des inhibiteurs de PDE10, des compositions pharmaceutiques contenant de tels composés et des procédés de fabrication de tels composés. L'invention concerne également des procédés de traitement de maladies induites par l'enzyme PDE10, telles que l'obésité, le diabète non insulinodépendant, la schizophrénie, le trouble bipolaire, le trouble obsessionnel-compulsif et similaires.
Arrington Mark P.
Conticello Richard D.
Hess Hans-Jurgen
Hitchcock Stephen A.
Hopper Allen T.
Amgen Inc.
Memory Pharmaceuticals Corporation
Osler Hoskin & Harcourt Llp
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