Cinnoline-carboxamides and process for their preparation

Details Cinnoline-carboxamides and process for their preparation Cinnoline-carboxamides and process for their preparation

C - Chemistry, Metallurgy

07

D

167/208, 260/264

C07D 237/28 (2006.01) A61K 31/50 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 1309407

25521-136 ABSTRACT Cinnoline-carboxamides The invention relates to compounds having the general formula (I) Image (I) wherein n is zero, 1 or 2; each of R1 and R2 is independently: a) hydrogen, halogen, trifluoromethyl or C1-C6 alkyl; b) hydroxy, C1-C6 alkoxy or C3-C4 alkenyloxy; c) nitro, amino, formylamino or C2-C8 alkanoylamino; R3 represents hydrogen or C1-C8 alkyl; R4 is: a') C1-C20 alkyl, unsubstituted or substituted by Image wherein each of Ra and Rb is independently phenyl or C1-C6 alkyl, or Ra and Rb, taken together with the nitrogen atom to which they are linked, form a N-pyrrolidinyl, N-piper- azinyl, hexahydroazepin-1-yl, thiomorpholino, morpholino or piper- idino ring, wherein said heterocyclic rings may be unsubstituted or substituted by C1-C6 alkyl or phenyl;

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